MovDisordV3, Main, Exploration, bibRecord, 003A81

Imaging of activated microglia with PET and [11C]PK 11195 in corticobasal degeneration

Identifieur interne : 003A81 ( Main/Exploration ); précédent : 003A80; suivant : 003A82

Imaging of activated microglia with PET and [11C]PK 11195 in corticobasal degeneration

Auteurs : Karsten Henkel [Allemagne] ; Jochen Karitzky [Allemagne] ; Michaela Schmid [Allemagne] ; Irina Mader [Allemagne] ; Gerhard Glatting [Allemagne] ; Jürgen W. Unger [Allemagne] ; Bernd Neumaier [Allemagne] ; Albert C. Ludolph [Allemagne] ; Sven N. Reske [Allemagne] ; G. Bernhard Landwehrmeyer [Allemagne]

Source :

[ 0885-3185 ]

RBID : ISTEX:7930AC996B7CBE42DA915192A78E38EDFD8493BE

Descripteurs français

Pascal (Inist)
- Dégénérescence, Microglie, Positon, Système nerveux pathologie, Tomoscintigraphie.

English descriptors

KwdEn :
- Aged, Basal Ganglia Diseases (metabolism), Basal Ganglia Diseases (pathology), Basal Ganglia Diseases (radionuclide imaging), Cerebral Cortex (metabolism), Cerebral Cortex (pathology), Cerebral Cortex (radionuclide imaging), Degeneration, Emission tomography, Functional Laterality (physiology), Humans, Isoquinolines (diagnostic use), Magnetic Resonance Imaging, Male, Microglia, Microglia (metabolism), Microglia (pathology), Microglia (radionuclide imaging), Nerve Degeneration (metabolism), Nerve Degeneration (pathology), Nerve Degeneration (radionuclide imaging), Nervous system diseases, Positron, Radiopharmaceuticals (diagnostic use), Receptors, GABA-A (metabolism), Tomography, Emission-Computed.
MESH :
- chemical , diagnostic use : Isoquinolines, Radiopharmaceuticals.
- metabolism : Basal Ganglia Diseases, Cerebral Cortex, Microglia, Nerve Degeneration, Receptors, GABA-A.
- pathology : Basal Ganglia Diseases, Cerebral Cortex, Microglia, Nerve Degeneration.
- physiology : Functional Laterality.
- radionuclide imaging : Basal Ganglia Diseases, Cerebral Cortex, Microglia, Nerve Degeneration.
- Aged, Humans, Magnetic Resonance Imaging, Male, Tomography, Emission-Computed.

Abstract

Positron emission tomography (PET) using [11C]PK 11195, a ligand for peripheral benzodiazepine receptor binding sites, offers the opportunity to image activated microglia in vivo. This tool may therefore be used to display the occurrence of microglial activation in the course of neurodegeneration. A patient with the clinical diagnosis of corticobasal degeneration (CBD) and left‐sided symptoms was studied using fluorodeoxyglucose (FDG) and [11C]PK 11195 PET. We found a marked right hemispheric hypometabolism and asymmetric microglial activation in corresponding areas of the basal ganglia and right temporal and parietal cortex. [11C]PK 11195 PET suggests involvement of microglial activation in the pathogenesis of CBD. © 2004 Movement Disorder Society

DOI: 10.1002/mds.20040

Affiliations:

Le document en format XML

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<author><name sortKey="Reske, Sven N" sort="Reske, Sven N" uniqKey="Reske S" first="Sven N." last="Reske">Sven N. Reske</name>
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<term>Basal Ganglia Diseases (metabolism)</term>
<term>Basal Ganglia Diseases (pathology)</term>
<term>Basal Ganglia Diseases (radionuclide imaging)</term>
<term>Cerebral Cortex (metabolism)</term>
<term>Cerebral Cortex (pathology)</term>
<term>Cerebral Cortex (radionuclide imaging)</term>
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<term>Microglia (pathology)</term>
<term>Microglia (radionuclide imaging)</term>
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<term>Nerve Degeneration (pathology)</term>
<term>Nerve Degeneration (radionuclide imaging)</term>
<term>Nervous system diseases</term>
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<term>Radiopharmaceuticals (diagnostic use)</term>
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<term>Microglia</term>
<term>Nerve Degeneration</term>
<term>Receptors, GABA-A</term>
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<term>Cerebral Cortex</term>
<term>Microglia</term>
<term>Nerve Degeneration</term>
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<keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Basal Ganglia Diseases</term>
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<term>Nerve Degeneration</term>
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<term>Tomography, Emission-Computed</term>
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<term>Microglie</term>
<term>Positon</term>
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<front><div type="abstract" xml:lang="en">Positron emission tomography (PET) using [11C]PK 11195, a ligand for peripheral benzodiazepine receptor binding sites, offers the opportunity to image activated microglia in vivo. This tool may therefore be used to display the occurrence of microglial activation in the course of neurodegeneration. A patient with the clinical diagnosis of corticobasal degeneration (CBD) and left‐sided symptoms was studied using fluorodeoxyglucose (FDG) and [11C]PK 11195 PET. We found a marked right hemispheric hypometabolism and asymmetric microglial activation in corresponding areas of the basal ganglia and right temporal and parietal cortex. [11C]PK 11195 PET suggests involvement of microglial activation in the pathogenesis of CBD. © 2004 Movement Disorder Society</div>
</front>
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<tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Henkel, Karsten" sort="Henkel, Karsten" uniqKey="Henkel K" first="Karsten" last="Henkel">Karsten Henkel</name>
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<name sortKey="Glatting, Gerhard" sort="Glatting, Gerhard" uniqKey="Glatting G" first="Gerhard" last="Glatting">Gerhard Glatting</name>
<name sortKey="Henkel, Karsten" sort="Henkel, Karsten" uniqKey="Henkel K" first="Karsten" last="Henkel">Karsten Henkel</name>
<name sortKey="Karitzky, Jochen" sort="Karitzky, Jochen" uniqKey="Karitzky J" first="Jochen" last="Karitzky">Jochen Karitzky</name>
<name sortKey="Karitzky, Jochen" sort="Karitzky, Jochen" uniqKey="Karitzky J" first="Jochen" last="Karitzky">Jochen Karitzky</name>
<name sortKey="Landwehrmeyer, G Bernhard" sort="Landwehrmeyer, G Bernhard" uniqKey="Landwehrmeyer G" first="G. Bernhard" last="Landwehrmeyer">G. Bernhard Landwehrmeyer</name>
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<name sortKey="Mader, Irina" sort="Mader, Irina" uniqKey="Mader I" first="Irina" last="Mader">Irina Mader</name>
<name sortKey="Neumaier, Bernd" sort="Neumaier, Bernd" uniqKey="Neumaier B" first="Bernd" last="Neumaier">Bernd Neumaier</name>
<name sortKey="Reske, Sven N" sort="Reske, Sven N" uniqKey="Reske S" first="Sven N." last="Reske">Sven N. Reske</name>
<name sortKey="Schmid, Michaela" sort="Schmid, Michaela" uniqKey="Schmid M" first="Michaela" last="Schmid">Michaela Schmid</name>
<name sortKey="Unger, Jurgen W" sort="Unger, Jurgen W" uniqKey="Unger J" first="Jürgen W." last="Unger">Jürgen W. Unger</name>
</country>
</tree>
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Movement Disorders (revue)

Imaging of activated microglia with PET and [11C]PK 11195 in corticobasal degeneration

Imaging of activated microglia with PET and [11C]PK 11195 in corticobasal degeneration

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.